Sofosbuvir – The Latest Cure for Hepatitis C Patients


Sofosbuvir is a novel drug that is used to cure Hepatitis C. The drastic advantage Sofosbuvir brings is that it is the first all-oral treatment for Hep C patients.


  • High Cure Rate (around 90%)
  • All-Oral (no injections)
  • Faster Treatment
  • No known resistance (as in the case with interferon)

Check out a comparison of Hepatitis C drugs for every genotype (like Harvoni vs Sovaldi). The latest addition to modern Hepatitis C treatment is Merck's Zepatier which cures genotypes 1 and 4 but at a very reduced price (Zepatier costs $54,600 while Harvoni costs $94,500 in the US).

Update: On 28th of June 2016 FDA approved the first pan-genotype Hepatitis C treatment called Epclusa. It comes with a $74,760 price tag and is highly effective for all Hep C genotypes. The generic version called Sofosvel costs only $840, for comparison.

Before Sofosbuvir the existing treatment consisted of interferon and antiviral drug ribavirin. The problem with interferon is that it has to be administered directly into the bloodstream with the use of a syringe. In addition, interferon is also considered responsible for the majority of Harvoni side effects connected with Hepatitis C treatment. Treatment could last up to a whole year.

Sofosbuvir, on the other hand, can be used to treat different kinds of Hepatitis C without having the interferon-related side effects. Ribavirin is used in combination with Sofosbuvir to enhance the Hep C treatment. Studies have shown that Sofosbuvir can also heal patients who developed resistance to existing Hep C treatments such as interferon. This new treatment lasts from 12 to 24 weeks and has been clinically proven to work in 90% of cases tested.


SofosbuvirTo put Sofosbuvir in perspective, one has to know a thing or two about Hepatitis C. Two words are connected with any hepatitis, namely VIRUS and LIVER.

Hepatitis C is a viral disease affecting the liver. It is usually without symptoms, which makes it difficult to detect and diagnose. Upon detecting it, the most effective treatment is vital – and here Sofosbuvir comes in as a life-saver. In absence of treatment, the Hepatitis C Virus scars the liver, which leads to liver cirrhosis – a disease often associated with chronic alcoholism. This can eventually lead to liver failure, for which liver transplant is the only treatment. The newly developed drug is designed to heal this potentially life-threatening disease.


The first thing a doctor suspecting Hep C infection will do is order blood work. This will tell him if antibodies against HCV are present in the bloodstream via ELISA test. The problem here is that in most cases antibodies appear 2-3 months after the infection, in some cases even after half a year. Our system has a way of delayed reactions: for example in drug tests there is no lack of people wondering how to pass a urine drug in 24 hours. It's not really possible because medicines can ‘hide' in out fat and are eliminated during a longer time period.

So if you don't have antibodies that does not necessarily mean that you don't have Hep C. On the other hand, if you have antibodies, that does not necessarily mean you have Hep C – this is in the case when the immune system successfully fought of the infection, and all that remained are the antibodies in the bloodstream. That's why when test on antibodies is positive, a doctor will order PCR test to detect Hepatitis C virus in bloodstream. For this purposes test were developed that can give the information in under 30 minutes.

Here is a Hepatitis C patient testiment.

 I am tired all the time. I have stomach pains. Feel shortness of breath often. I have a metallic taste in my mouth all the time. I am afraid family might get it, although I've been told that it has to be blood-to-blood contact. I still feel like I am harbouring a dangerous monster.

This patient is well aware of the problem he's having, the next step is to correctly diagnose Hepatitis C with medical test – read more about diagnostics tests for Hep C.


Since the market release of Sofosbuvir on 6th of December 2013, there are two viable treatments for Hepatitis C.


Interferon treatment is the golden standard for Hepatitis C treatment since the late 1980s.


Sofosbuvir in the latest medicine for Hepatitis C. It is the first all-oral treatment for Hep C, taken together with Ribavirin. Treatment with Sofosbuvir lasts for 12 to 24 weeks, which is half the time of the treatment with interferon. The cure rate is about 90% which is a drastic increase from 50-60% with interferon.


The first Sofosbuvir drug Sovaldi by Gilead Sciences was approved by FDA on 6th of December 2013. It was registered to be used for chronic hepatitis C infection, combined with other antivirals such as Ribavirin. This regiment  is the first one that is all-oral because the most basic treatment does not include interferon, an antiviral drug that must be injected.

Here is a video by Joe Galati MD that will change your perspective on Hepatitis C big time:

Depending on the type of chronic hep C, different kinds of treatment regiments are used.

For genotype 2 chronic hep C a mixture of Sofosbuvir (Sovaldi) and Ribavirin are used, with treatment duration of 12 weeks.

For genotype 3 the same mixture is used for 24 weeks.

For genotype 1 and genotype 4 chronic hepatitis C Interferon is added to the mixture and the treatment last for 12 weeks.

As you see, the treatment with Sorosbuvir drug lasts half as much time as previous treatment based only on Ribavirin and Interferon. The usual dosage is 400 mg Sovaldi pill taken orally once per day for the recommended period of time.

You can see the timeline Sofosbuvir went through to finally get to the hepatitis patients.


Majority of drugs exhibit drug interaction and Sofosbuvir is not an exception. There are predominately two ways other drugs can effect Sovaldi pill – they can increase or decrease Sofosbuvir action. If the drug action is decrease the pill will not heal the Hep C as effectively. On the other hand, increase in Sovaldi's action may lead to more side effects of the drug. Below is a table that reveals which drugs interact with Sofosbuvir.

Interacting drugEffect on Sofosbuvir Treatment significance
Antiepilepic drugs (carbamazepine, phenytoin) Decreases Sofosbuvir concentrationReduces Sovaldi's therapeutic effect
Antimycobacterials associated with tuberculosis treatment (rifampin)Decreases Sofosbuvir concentrationReduces Sovaldi's therapeutic effect
Herbal Suppliments (St. John's wort)Decreases Sofosbuvir concentrationReduces Sovaldi's therapeutic effect
HIV drugs (tipranavir)Decreases Sofosbuvir concentrationReduces Sovaldi's therapeutic effect


harvoni sofosbuvir ledipasvir medicine for hepatitis cWith mixture Sofosbuvir + Ribavirin the most common side effect was fatigue and headaches, which effected more than 20% of test subjects. Adding Interferon to the mixture to treat genotype 1 and 4 Hepatitis C caused, in addition to fatigue and headaches, insomnia, anemia and nausea. This adverse effects were also seen in more than 20% of test subjects. Notably, without Interferon, certain adverse effect, such as insomnia and nausea, were found to be less frequent. On the other hand, clinical studies have shown that fatigue and headaches, normally associated with Interferon Hep C treatment, are less frequent and less severe.

The most common Harvoni side effects can be troublesome; but you can do much by drinking plenty of water and exercising. Additionally, you can maintain a healthy and functioning liver using the appropriate liver health supplements. It's also a good way to stay away other drugs; you don't want to end up using synthetic urine to pass drug tests. And of course, it hurts the liver.

The most problematic side effect after the treatment is weight gain. Some patients can even gain 30 pounds while on 12-week Harvoni or Sovaldi treatment. There is an effective way of shedding this fat and you can read more about it in weight gain while on Harvoni treatment here.


Sofosbuvir acts by inhibiting the replication of RNA polymerase which is vital for Hepatitis C Virus (HCV) to grow. Without the ability of the virus to grow, the immune system will be able to fight the infection of in majority of cases, thereby healing a Hepatitis C patient.

Biologically Sofosbuvir mimics a chemical that virus uses to construct its own RNA polymerase of. When Sofosbuvir is incorporated in RNA polymerase construction, it prevent further construction – therefore the virus is stuck with useless half-constructed RNA polymerase. With such a problem, the Hep C virus is unable to replicate and is destroyed by our immune system.



Sovaldi is a newly developed drug that just got approved by the FDA. The prices of healing regiment of this arguably most effective hepatitis C treatment are exceptionally high. The price present in world media is that a 12 week treatment costs $84,000, while a 24 week treatment cost astonishing $164,000. However, the prices in UK are supposed to be around £35,000 for 12 week treatment.

On the other hand, there is a pressure to reduce the price of Sofosbuvir cost by both medical professionals and patients alike. Gilead Sciences, the Sovaldi manufacturer, is known for it's affordable HIV treatment for patients in third world countries. Accordingly, the company reported that they are in talks with many Indian generic companies. The idea is that by hiring them they could lower the costs of production and thereby lower the price of Sovaldi treatment in developing markets. Expected price ranges from high hundreds to low thousands of US dollars.

Check out Harvoni prices in US, Canada, Europe and more.

11 thoughts on “Sofosbuvir – The Latest Cure for Hepatitis C Patients

  • January 26, 2017 at 4:11 pm

    I just wanted to leave feedback for anybody that cares i didnt see these side effects before i started treatment, dont get me wrong i still would do it over again cause i want to be healed, BUT my side effects are getting worst and worst through out this journey im currently on my 6th week of a 12 week regiment, im having SEVERE depression,hopelessness, irritability,agitation,and moodiness really bad all i want to do is cry and it’s about things that never would’ve mattered before i feel bipolar now i cant control my feelings i snap for no reason. Ive had an occasional headache but i had headaches before treatment so there no big deal nausea no big deal but the emotional things and loss of pleasure ,tiredness is overwhelming i cant WAIT till i feel normal i wonder if anybody had or is having these issues if anybody reading this can relate please write back i really need support i cant tell a whole lot of people cause they won’t understand so if somebody can help i would greatly appreciate it alot. Thank you.

  • November 15, 2016 at 6:38 pm

    I have just started my 12 week regimen of Zepatier today, 11/15/2016, I will report to every one as to my progress after my 4 week follow-up, wish me luck!

    • November 16, 2016 at 11:55 pm

      Good luck! Wish you achieve SVR!

  • October 19, 2016 at 12:15 am

    Please can any one let me know a trustworthy pharmacy in India were we can get the harvoni medicine ? very much in need of the medicine, insurance have denied us twice. with appeals written.

  • September 27, 2016 at 12:08 pm

    Is there anyone with experience in ordering the medicine from India, instead of actually traveling there? I live in Hungary, and my doctor advised going there, because appearantly one might not get the right medicine delivered – I would like to know if someone knew about any trustworthy way to order it?

  • June 20, 2016 at 10:29 pm

    Available to travel to India to purchase harvoni. how can I buy the step-by-step instructions of how to contact Indian doctors, get a prescription, a valid distributor and so on?

  • May 9, 2016 at 1:42 am

    As a soldier in the U.S.Army in the 1970s, I became an attractant to metal, resulting in transfusions 7 times. One of these was contaminated with hep c. Now, as a 100 % disabled veteran and 40 years later, the V.A. is treating my hep c with Harvoni. 8 weeks ago my viral count was 14,5000,000. Yesterday it was undetectable,and the cost to me was paid years ago while the financial cost is zero dollars. I would like to thank the citizens of the United States for making your voices heard in congress, so that we, the bloodied warriors continue to receive necessary treatments. Now if we can get help for the 22 vets per day who commit suicide and the 50,000 homeless vets we will have not only won the battle but the war.

  • February 29, 2016 at 4:07 pm

    Hi the closest country to Pakistan .i am wondering how to buy harvoni I asi couldn’t find any information related in your webs to I am looking forward to hearing from you your sincerely Masood Arif butt

  • February 15, 2016 at 4:16 pm

    hi im contacting from Iran.I am wondering how to buy harvoni as i couldn’t find any information related in your website. I am looking forward to hearing from you.

    • May 17, 2016 at 1:20 am

      I need to buy Harvoni for my important relatives in China, could you please recommend an reliabe pharmacy in India with a good reputation and lower price? and its contact information, email, phone et al. Thank you very much!


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