Even wonder drugs have adverse effects. Harvoni is not an exception. Harvoni side effects are, in general, mild.
Probably you're wondering:“What are side effects of Harvoni?”
We will come to that in a moment. Let us consider the next question:“How do I reduce side effects when on Harvoni?”
Side effects are given. What we can do, however, is to try to elevate them as much as possible. We'll give you two options for every side effect, such as headaches and fatigue: OTC drug (stronger) and natural remedy (milder). You can decide which works best for you.
How to do that? Let us start with a short summary of Harvoni side effects and natural supplements used to elevate them.
Harvoni side effects
Some patients complain about weight gain as well. A short diet with a help of Garcinia Cambogia (more than 10,000 reviews for weight loss) during or after treatment should bring your body weight back to normal, or even make you loose some pounds extra.
Here are some parts of the body that Harvoni can affect, according to HealthLine:
How Frequent are Harvoni Side effects?
How many people experience side effect because of Harvoni use? The clinical trials with genotype 1 patient have revealed what kind of side effects Harvoni causes. What is more, we learned how frequent they are.
More than 500 Hepatitis C patients were involved in such a study. They were on a standard 12-week treatment. Here are the results for Harvoni side effects, according to RxList:
- The most common side effect of Harvoni treatment was headaches. 14% of patients suffered the most prevalent Harvoni side effect.
- The close second was fatigue. On the whole, 13% experience being without much energy or motivation as a consequence of Harvoni treatment.
- Nausea was seen as a side effect of Harvoni in 7% of patients.
- Furthermore, 5% and 3% of patients suffered from nausea and diarrhea, respectively.
On a whole, patients undergoing 12-week treatment experienced less mild side effect of Harvoni such as headaches and fatigue. However, patients on 8-week or 24-week treatment didn't experience exceedingly more side effects when on Harvoni.
Here is the whole data from the clinical trials. It is worth noticing that 12-week treatment yielded the least frequency Harvoni adverse effects:
Most Common Harvoni Adverse Effects – Fatigue and Headaches
Fatigue is a drag on for most Hepatitis C patients. It is really important to do important things like work or chores when you feel you have more energy.
Taking short naps is also a great option, just don't do it before bedtime because insomnia might kick in and you won't be able to sleep.
Usually drinking water and eating healthy also raises alertness. The only problem is that most of us are doing that already even if we're not on Harvoni. It is very good that while we're on Harvoni to give ourselves extra boost of energy with vitamins, be it for 12-week or 24-week treatment.
Natural supplements to help with Fatigue or Tiredness
For More EnergyEnergy boosting supplements are the usually the best choice to counter tiredness and fatigue.
Grass Green will elevate energy levels in a natural way. Caffeine supplement will boost it in a rapid way.
|For Energy:||Natural and Mild||Caffeine Energy Boost|
|Avg. Rating:||(4.3 / 5)||(4.2 / 5)|
Natural supplements to help with Headaches
Headaches are another matter.
Drinking plenty of fluids is always a good call as is avoiding coffee or tea because they dehydrate the body. Some people even start using detox drinks such as QCarbo16 in order to urinate more and detoxify the body.
Usually when people have headaches they use NSAID painkillers drugs like aspirin. But that is not a good idea for treating Harvoni-induced headaches because treatment lasts for 12 or so weeks, and taking aspirin every day for 12 weeks can damage stomach walls and cause ulcerous.
Most of Hepatitis C patients find milder natural and herbal supplements to do the job. Aspirin is essentially a drug while vitamins and herbal headache pills are of natural origin.
Pain ReliefSome people opt for OTC painkillers when it comes to headaches. However, that is true if you have an occasional headache. If you're having them for 3 months straight, a milder but effective version could be a smarter choice.
|Pain Relief:||Milder Smoothing Brain Support||Stronger OTC Painkiller|
|Avg. Rating:||(4.3 / 5)||(4.8 / 5)|
Nausea can occur with 3-8% of Harvoni patients as a side effect, depending on the Hepatitis C treatment regime length.
This is one of Harvoni side effects that cannot be dealt with easily by drinking more or resting more often.
Most of Hepatitis C patients opt for natural remedies that are very safe to use and efficient at getting rid of nausea. For more heavy medication you will need a doctors prescription.
Anti-Nausea ChoicesYou can opt for stronger or milder version. What is very important when it comes to nausea is choosing the right and healthy nutrition - can make a difference.
|Anti-Nausea Choices:||Stronger Chewable Pills||Milder Natural and Herbal|
|Avg. Rating:||(4.2 / 5)||(4.2 / 5)|
One of the most unwanted side effects of Harvoni is diarrhea.
With nausea or tiredness patients can find a way to handle it, but constant diarrhea is something that can completely block us from living a normal life when on Harvoni treatment.
For use in such long periods advanced probiotics are the key.
Some things from your local store can also help; yogurt is a fine example of natural probiotic for mild cases but for longer Harvoni treatment what usually helps is advanced probiotics to combat Harvoni side effects.
Diarrhea HelpOne of the smartest ways of treating diarrhea is with probiotics. If you take care of healthy bacteria in your gut, you can in many cases prevent diarrhea. For more serious cases, try referring to stronger loperamide-based medicines.
|Diarrhea Help:||Milder Natural Probiotics||Stronger Loperamide-Based Anti-Diarrhea Medicine|
|Avg. Rating:||(4.5 / 5)||(4.8 / 5)|
Dealing with insomnia as Harvoni side effect can be tricky.
Harvoni causes fatigue. Sleep is very important to gain energy every day. However, most of the drugs prescribed for insomnia work by taking energy away from you in order to sleep. Here is a story of one Hepatitis C patients on Harvoni:
This dilemma can be solved by mild anti-insomnia aids. They are strong enough to help you sleep but you don't get drug dependency as with most insomnia prescription drugs.
Thus after Harvoni treatment everything will turn to normal and you will be able to sleep without pills, while with stronger pills there is a risk of becoming dependent and being unable to fall asleep without the pill.
For Easier SleepHaving restless nights can be a bother and an energy drain. For mild insomnia, herbal aids can be very much effective. For extreme cases, try stronger sleeping pills.
|For Easier Sleep:||Milder Natural Sleeping Aid (with Chamomile)||Stronger Sleeping Pills|
|Avg. Rating:||(4.2 / 5)||(3.7 / 5)|
Severe side effects of Harvoni
Usually common side effects such as headaches and fatigue are easier to handle with basic medicines. There are, however, severe side effects of Harvoni that occur in less than 1 in 100 patients. These can include the following:
- Allergic reaction on skin: itching, rash, and face, lips of tongue swelling
- Allergic reaction in lungs: tightness in chest, difficulty breathing
- Cardiovascular: cardiac arrest, heart problems
Read more about severe side effects of Harvoni at drugs.com.
Rashes and Itching as Harvoni Side Effects
The most common severe side effect of Harvoni is a rash and itching. This is a result of an allergic reaction between sofosbuvir, active ingredient in both Harvoni and Sovaldi, and your immune system. Usually, skin or lungs are where the results of allergic reaction is most visible.
This kind of Harvoni side effects can have serious consequences. Therefore always check with your doctor about allergic reactions such a rashes or tightness in the chest.
FDA alert for Hepatitis C patients – Risk of Hepatitis B reactivation
In October 2016 FDA issued an urgent notice – some 24 patients being treated with Hepatitis C medications saw reactivation of Hepatitis B.
Here is the following statement by FDA (read full statement here):
ISSUE: The FDA is warning about the risk of hepatitis B virus (HBV) becoming an active infection again in any patient who has a current or previous infection with HBV and is treated with certain direct-acting antiviral (DAA) medicines for hepatitis C virus. In a few cases, HBV reactivation in patients treated with DAA medicines resulted in serious liver problems or death. HBV reactivation usually occurred within 4-8 weeks.
A Boxed Warning will be added to those Hepatitis C medications that cause Hepatitis B reactivation. You are advised to talk to your physician if any symptoms of Hepatitis B appear after treatment.
Here is a summary of FDA statement on Medscape.
Weight Gain as Harvoni Side Effect
Harvoni users have, among very successful cure rate, reported weight gains. It seems that weight gain is Harvoni side effect. One of the patients had this story to tell:
I'm in 8th week into 12 week Harvoni treatment. I don't have visible side effects but I have started gaining weight. I haven't changed my diet, still do lots of activities and sports, drinking plenty of fluids. Should I eat less when on Harvoni? Is weight gain Harvoni side effect?
This is not the only reference to weight gain presumably cause by Harvoni treatment. Insomnia and fatigue might be the cause for Hepatitis C patients on Harvoni to be less active and burn less calories.
However, the connection between Harvoni use and weight gain has not been officially confirmed. If you have any such kind of experiences, you can report Harvoni side effects to FDA. You will find one of the best ways of how to reduce weight gains and even lose fat is our Harvoni and weight gain section.
To prevent weight gain and ensure you stay in shape, weight loss Garcinia Cambogia is recommended. It comes in a 90 pill package that correlates to 12-week treatment and doesn't not interfere with Harvoni treatment.
Here is a testimonial of a patient with Hepatitis C taking Harvoni for 8 days.
Harvoni side effects after treatment
All Harvoni effect, the ones that cure Hepatitis C and the adverse effect, stop some days after the last Harvoni pill.
A vast majority of patients are happy because they have been healed and there in no Hepatitic C virus present in their blood. Some do inquiry about fatigue and headaches, most common Harvoni side effects, and when will the side effects go away.
Usually it takes 1-2 days for the body to clear of sofosbuvir and ledipasvir, active ingredients in Harvoni. This is very fast because both of the substances are water soluble and are easy washed out of the body via kidneys.
Patients who were suffering from side effects recover their normal state in 2 days.
Harvoni Side Effect with Alcohol
In most cases taking drugs with alcohol increases the intensity and frequency of side effects.
Harvoni side effects with alcohol have not been studied but this Hepatitis C treatment is no exception as far as consuming it together with alcohol is concerned.
Harvoni works on the liver, this is the same organ that metabolizes alcohol in order for it to leave the body. There is a high probability for interaction between Harvoni and alcohol which would increase Harvoni side effect.
In the case when a patient is a heavy drinker this might be a serious problem, and doctors advise firmly against alcohol while taking Harvoni.
Patients have a lot at stake while taking Harvoni. Not only are they getting a cure for deadly Hepatitis C,
Not only are they getting a cure for deadly Hepatitis C, cost of Harvoni is also substantial with standard 12-week treatment price of $94,500 in the US.
Alcohol is an additional risk to treatment and most of the patient find the will to not touch the glass during and even after the treatment. Here is what people think about Harvoni side effects with alcohol.
Side effects of Harvoni vs Sovaldi
Sovaldi in Harvoni's predecessor with a bit lower cure rate. Sovaldi contains 400 mg of sofosbuvir, while Harvoni contains 400 mg of sofosbuvir and 90 mg of ledipasvir. The essential difference is that
The essential difference is that Harvoni contains ledipasvir and additional side effects can be due to that active substance. This would prompt us to believe that Sovaldi has less side effects than Harvoni. But in fact the opposite is true. Why?
Because in many cases treatment of Hepatitis C with Sovaldi requires to take additional ribavirin pills, and in less cases even interferon. Sovaldi, taken by itself, has similar side effects as
Sovaldi, taken by itself, has similar side effects as Harvoni to a similar degree. However, due to effects of ribavirin and interferon Hepatitic C treatment with Sovaldi has more severe side effects. Nonetheless most patients do not experience any of them and 1 in 5 might experience fatigue and headaches.
Harvoni is a stand-alone cure. Patients don't need to intake anything else to fight Hepatitic C virus and therefore has less adverse effects. Being the most successful Hep C drug on the market, it is doctor's first choice concerning Hepatitis C treatment. Considerations, however, are in place because of the high cost of Harvoni and Sovaldi.
Being the most successful Hep C drug on the market, it is doctor's first choice concerning Hepatitis C treatment. Considerations, however, are in place because of the high cost of Harvoni and Sovaldi.
Importance of Taking Care of Your Liver
Hepatitis C treatment will only get rid of your Hepatitis C-related problems.
It is important to always take care of your liver, before treatment, during treatment as well as after treatment. The best way to keep the lift and keep the healthy liver functions is by having a healthy and balanced diet as well as exercising. Natural supplements can additionally boost liver functions and speed up liver detoxification.
There are some very good liver detoxification natural supplements such as Liver Cleanse Detox Supplements containing milk thistle and uva-ursi extract to name just a few. Liver Cleanse Detox does not only help upkeep normal liver functions, but also boosts energy and promotes weight loss.
Other natural supplements for liver detoxification and healthy liver functions include:
- European Milk Thistle Extract (The #1-selling herb for maintaining the functional efficacy of the liver)
- Detoxification I and II Phase Factors (Shields the liver against the oxidative stress)
- Liver Support & Cleanse Supplement (More affordable advanced liver protection formula)
Keep in mind that using natural supplements can slow down the process of liver cirrhosis in Hepatitis C patients, according to several key studies.
Side effects of Harvoni were discovered in clinical trials
Gilead Sciences, the company making Harvoni and Sovaldi, conducted thorough clinical studies prior to FDA approval in order to best evaluate side effects Hep C patients might expect when using Harvoni.
Harvoni side effects come from active molecules called sofosbuvir and ledipasvir. Sovaldi, on the other hand, consists only of 400 mg of sofosbuvir, and has thus less side effects than Harvoni. Nonetheless, doctors and patient alike prefer Harvoni despite $94,500 price per treatment because of its effectiveness fighting Hepatitis C virus – successful cure rate it over 95%.
Harvoni side effects are general for all Hepatitis C genotypes. However, some medication side effects are specific to each Hep C genotype. In this article we will answer they questions and what are Harvoni side effects, how common are Harvoni side effects and what are the best solutions to lessen side effects of Harvoni.
Share your Harvoni side effects
Most everything we know about new drug side effects comes from clinical studies done by Gilead in the case of Harvoni.
With people being prescribed the drugs we gain new knowledge about possible Harvoni side effects. So if you have some insight or personal experience with side effects of Harvoni, please state them in the comments to help other Hepatitis C patients on Harvoni understand what they can expect and how to treat it.
It is very important to know what side effects of any drug are in order to understand than things like fatigue and headaches in the case of Harvoni side effects are natural. This is also how we get to know how to treat such side effects, by the use of B12 vitamin or advanced probiotics and so on.
We would wish everybody on Harvoni to be side effect free. It truly is a wonderful drug with over 95% cure rate of a deadly disease. Few adverse effects of Harvoni only make it a better medicine.